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In general, the prevalence of melanosis coli in a population tends to increase with age.9 However, it has been reported in a child as young as four years of age.10 The author is not aware of any local statistics on this condition, but is of the impression that melanosis coli is by no means uncommon in colonoscopies performed locally

As radiation exposure and LPS stimulation activate inflammasomes (including NLRP3 and AIM2)key molecular complexes that trigger pyroptosisthis process directly contributes to disease development in both pneumonitis types [56-60]

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