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then, protein C atoms and heavy atoms of AdoCbl/OHCbl and Cobalt were restrained to minimise/equilibrate (2 ns) main chain of protein

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This synthesis of vitamin B 12 is of no practical consequence due to its length, taking 72 chemical steps and giving an overall chemical yield well under 0.01%

Immune-mediated: Antibody-mediated (anti-ganglioside antibodies in GBS/MMN, anti-CNTN1 in CIDP variants)