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This classification bans compounding pharmacies from dispensing these substances due to potential safety hazards [5]

In contrast, the AIM-HIGH (Atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides: impact on global health outcomes) trial, which examined the incremental effect of extended-release nicotinic acid (1.5-2 g/day) on 3,414 patients who had established CVD and atherogenic dyslipidemia and were treated with simvastatin (+/- ezetimibe), provided disappointing results

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The approach taken by EPA and international public health organizations relies on assigning each compound (dioxins, other than TCDD, and DLCs) a toxic equivalency factor, which is an estimate of the toxicity of the compound relative to TCDD