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Carnitine can effectively inhibit mitochondria-dependent apoptosis by regulating the balance of Bcl-2/Bax, inhibiting the mitochondrial permeability transition (MPT), and reducing mitochondrial membrane damage and the release of apoptosis-related factors [14, 15]

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TMAO and NF-B signaling NF-B is a master regulator of inflammation, and its activation by TMAO has been extensively documented

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