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Mechanisms of Antibiotic Resistance: Overview Bacterial resistance to antibiotics develops by intrinsic traits or by acquiring new genes or mutations
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In particular, we focused on the p21 N-terminal cyclin-CDK binding domain, required for inhibition of G1/S cell cycle progression, and the C-terminal PCNA binding domain involved in suppressing DNA synthesis (Chen et al, 1995) (Fig 2D)
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