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GSDMD, the pyroptosis executioner protein, forms plasma membrane pores via its N-terminal domain, causing cell death and releasing pro-inflammatory factors (IL-1, IL-18, HMGB1) that activate neighboring glial cells and recruit peripheral immune cells, amplifying neuroinflammatory feedback loops [49]

P2X7 receptor-mediated release of excitatory amino acids from astrocytes

Effects of Nitrogen Dioxide on Fatty Acid Compositions of Red Cell Membranes, Sera, and Livers in Rats

It requires hydrolysis by intestinal microbial -glucuronidase to be converted into the more lipophilic baicalein, which can then be efficiently absorbed into the bloodstream