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Eur Rev Med Pharmacol Sci 27:4665
(5) After internalization, B 12 is released and free B 12 is secreted into the blood, bound to transcobalamin and transported to peripheral organs/targets
It is interesting to point out that the same biological effect can be achieved through Igf-1 by activating different pathways in different cells: IIS induces proliferation in embryonic rat cortical progenitors in an Erk-independent manner, while Igf-1 signalling induces proliferation of adult hippocampal progenitors via Erk-dependent cytoplasmic downstream signals
10.1002/bmc.127 Biomed
