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The conservation of this lactate/SCD1 regulatory axis across diverse tissue types has been substantiated by multiple studies (80,81)

On the one hand, H 2 S increases glucose uptake and fat production in adipocytes, for example: (1) in 3T3L1 adipocytes, H 2 S improves high glucose-induced insulin resistance by up-regulating phosphatidylinositol 3,4,5-trisphosphate level, (2) in diabetic insulin resistance rats, NaHS and H 2 S gas solution improve insulin resistance by activating insulin receptors (IR), (3) CSE/H 2 S converts glucose into triglycerides in adipocytes through peroxisome proliferator-activated receptor (PPAR) and stores them in cells, (4) H 2 S promotes adipogenesis in 3T3L1 cells by increasing the expression of fatty acid protein 4 (8386)

When solutes are added to partitioning systems (multiphasic systems), they distribute according to their solubility in the various phases, a phenomenon widely employed in a plethora of applications, including basic science and relevant economic areas such as medicine, pharmacy and food technology

(2018) 102:e4958