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Description
Anti-inflammatory and Antifibrotic Effects of Estrogen The convergence of toxic stimuli such as insulin resistance, adipose tissue dysfunction, gut barrier dysfunction, lipotoxicity, hepatic endoplasmic reticulum stress, and mitochondrial dysfunction lead to a profound proinflammatory state that fuels the development of MASH
For example, ARA 290 significantly alleviated mechanical and cold allodynia in the spared nerve injury (SNI) model in both rats and mice and facilitated regeneration of small autonomic nerve fibers within sympathetic ganglia in diabetic neuropathy [183,184,185,186]
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