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doi: 10.1038/s41467-023-43283-2 96 XuSLiHHanJXuYLiNCheWet al

The presence of reduced GSH within mitochondria is especially crucial for preserving the organelles routine performance by eliminating hydrogen peroxide generated under both physiological and pathological conditions

Research has also shown that it decreases the activity of NF-B, an important protein that controls the production of inflammatory substances, and increases melanin synthesis

More specifically, one drug (amiodarone) limited hydrogenosomes localization to the cell periphery and induced an elongated shape, while the other (dronedarone) caused hydrogenosomes to present an emptied matrix [120]
