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Not surprisingly, these last genera have been associated with the ability of reducing intestinal permeability, with consequent decrease of endotoxin levels and improvement of glucose tolerance and systemic inflammation [55]

Down syndrome: Neurobiological alterations and therapeutic targets

conducted a CRISPR/Cas9 genetic screen with KEAP1 -mutant lung cancer cells and found that NRF2-addicted cancer cells are highly dependent on glutamine uptake, and that, consequently, inhibition of glutamine-derived glutamate by glutaminase inhibition effectively suppresses NRF2-addicted lung cancers (Romero et al

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