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The exposure to lead, manganese, solvents and some pesticides has been related to hallmarks of PD such as mitochondrial dysfunction, alterations in metal homeostasis and aggregation of proteins such as -synuclein (-syn), which is a key constituent of Lewy bodies (LB), a crucial factor in PD pathogenesis

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Conclusions NACs antioxidant and cytoprotective properties make it a promising therapeutic agent for a wide range of conditions in which oxidative stress plays a major role in the onset and progression of the disease

Thus, by examining this angle, we aim to reveal the mechanism by which FOXO4-DRI alleviates individual aging, providing a new perspective for the treatment of aging using FOXO4-DRI