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Given that core metabolic processes, including nucleotide synthesis, glycolysis, and redox defense, are fundamentally shared with normal proliferative tissues, broad-spectrum metabolic inhibition often lacks true selectivity and precipitates dose-limiting systemic toxicities [43]
doi: 10.1016/j.bbamcr.2015.01.010 271 PierdomenicoA
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Blood samples were taken, and both kidneys were removed from all rats
