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Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla

Researchers used LPS to establish a severe pneumonia mouse model, and genomic analysis confirmed that pulmonary endogenous bacteria can translocate to the brain and drive the transition of microglia and astrocytes from a resting state to an activated state via infection-associated pathways, thereby disrupting brain homeostasis [262]

The degree of photosensitivity varies among individuals

I want to be transparent about that gap rather than paper over it with confident citations
