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UV has complex and mixed effects on human health: it mediates natural synthesis of vitamin D and endorphins 3 , being at the same time the most ubiquitous physical carcinogen in our environment 4

The preoptic area integrates inputs from ascending thermoregulatory pathways in the brainstem and spinal cord that convey information from the body periphery [62, 63]

it is one of the oldest organs in the history of evolution

These particles include: LDL (low-density lipoprotein) the main driver of artery-clogging plaque VLDL (very-low-density lipoprotein) carries triglycerides and contributes to the buildup IDL (intermediate-density lipoprotein) a transitional form between VLDL and LDL Lipoprotein(a) a genetic cholesterol particle strongly linked to early heart disease Because it includes more than just LDL, many cardiologists now view non-HDL as a stronger marker for risk assessment than LDL alone