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Hepatocellular carcinoma cells, characterized by increased exposure to ROS, have been shown to induce the methylation of CpG islands (CpG islands refer to genomic regions characterized by a high abundance of CpG dinucleotides relative to other areas of the genome) within the cadherin promoter (Lim et al
In such cases, the defects are irregular in distribution, although there is a more or less severe loss of Purkinje cells
