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Recently, investigators developed an innovative device that allows in vivo microdialysis to simultaneously sample brain alcohol, acetaldehyde, and acetate while animals are ingesting alcohol (150)
In certain populations, 20-50% of individuals possess GST-related enzyme mutations or deletions [7]
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Earlier-phase proof-of-concept could reasonably use MRI-PDFF to show liver-fat reduction quickly and cheaply, but that would be a signal, not the answer
