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Previous studies have examined the potential effect of MH on the states of -syn in yeast, and similar effects were also observed in dopaminergic neurons of worms expressing 110

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We cannot rule out the possibility, however, that the exogenous, overexpressed nature of FARD-1::RFP in these experiments may result in a hyperactivated ether lipid biosynthesis state, thereby locking FARD-1::RFP localization in an activated configuration that cannot be further induced with biguanide treatment

PMID: 35718564