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By modulating this immunometabolic axis, GLP-1RAs may indirectly attenuate thyroid autoimmunity, supporting their potential role as dual-purpose agents in patients with coexisting metabolic and AITD

Atrophy in Leydig cell (L), hemorrhage in seminiferous tubules (yellow circle), and enlargement space between seminiferous tubules (green dotted arrow) (H&E, X 400)

Niculescu-Duvaz, D., Negoita-Giras, G., Niculescu-Duvaz, I., Hedley, D

This M1 polarization leads to increased expression of pro-inflammatory markers (such as CD80 and CD86) and cytokines (like IL-1, IL-6, and IL-12), while reducing levels of immunosuppressive cytokines such as IL-10