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doi: 10.1183/13993003.02244-2018 81 PhilippotQDesleGAdair-KirkTLWoodsJCByersDConradiSet al

Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)

HIF-1 is a transcriptional activator and a key regulator of the cellular adaptive responses to hypoxia and oxidative stress 25,26

Appl Biochem Biotechnol 193(4):10561071
