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Description
TMAO protects the structural and functional proteins of cells from damage by denaturing agents such as high osmotic pressure, hydrostatic pressure, NaCl, urea, or high temperature (71)

Accessed 11/3/2020, Furman JM, Barton JJ

Also, while it is generally considered safe, it appears it may decrease insulin sensitivity and even increase cardiovascular risk

This holds true even when people are in a calorie deficit or trying to lose weight
