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While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]

doi: 10.1016/j.biopha.2019.109249 22 ZiaAFarkhondehTPourbagher-ShahriAMSamarghandianS

For those with a temporary deficiency or improved dietary intake, our providers may recommend switching to oral supplements or eventually discontinuing injections altogetheralways under careful medical supervision

Diterpenoid architecture: labdane-type compounds belong to a specific pharmacological class