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This metabolic fingerprint has recently been recapitulated with mass spectrometrybased metabolomics in patients with type 1 and type 2 diabetes (8, 86, 110), validating earlier observations

Since oxidative stress caused by redox imbalance generates reactive oxygen species (ROS) which has been found to be significantly associated with colorectal cancer 8,13

More rigorous mechanistic validation, such as conditional knockout models and metabolic flux analysis, is required to distinguish driver roles from concomitant responses
Innovative Journal of Medical and Health Sciences, 3, 2325
