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Changes in sphingolipids Levels of some long-chain hydroxylated and non-hydroxylated sphingolipid species differed between the MPTP and Ctrl groups, with notable differences observed in the GPi and GPe regions of the basal ganglia (Fig

80 Beyond effects on platelets, it seems that the COX-1/TXA2 pathway contributes to vascular hypercontractility in atherosclerotic ApoE-deficient mice, targeting this pathway pharmacologically improves endothelial function

Vascular injury and perfusion heterogeneity generate and maintain hypoxia, stabilizing HIF1 and transcriptional programs that upregulate VEGF and CXCL12, thereby promoting angiogenic rebound and recruitment of CXCR4 bonemarrowderived cells after RTprocesses linked to radioresistance and tumor regrowth [112]

Nature 615:151157 Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, Srivastava A, Molla G, Madad S, Fernandez-Granda C et al (2024) Dictionary learning for integrative, multimodal and scalable single-cell analysis