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Increased tissue IGF-1R mRNA levels strongly correlate with poor patient clinical outcomes across different molecular BrCa subtypes [73], whereas IGF-1R is highly expressed in patients with early BrCa and overall positively associated with good prognostic variables

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Its ability to orchestrate adaptation to oxidants and electrophiles is due principally to stress-stimulated modification of thiols within one of its repressors, the Kelch-like ECH-associated protein 1 (Keap1), which is present in the cullin-3 RING ubiquitin ligase (CRL) complex CRL Keap1