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Last Reviewed: December 17, 2025 by Jose Vazquez, LVN
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One theory is that acetaminophen increases the pain threshold by inhibiting two isoforms of cyclooxygenase, COX-1 and COX-2, which are involved in prostaglandin (PG) synthesis
Taken together, these studies make a strong case for biased signaling for different MOR agonists between G protein activation and arrestin recruitment, at least for some agonists
