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Description
All these pathologies share a reduction in the glutathione pool that usually concurs with an increase in the production of ROS and RNS

Indeed, the investigation of cross talk between mentioned molecules and tumor stroma may shed light on finding new targets and could provide beneficial information for the rational design of a novel therapeutic approach in cancer

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Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death
