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Author Contribution Dehui Chang, Bin Zhang and Xuejun Shang contributed to the conception of the study

In this regard, the metabolic conversion of alcohol into acetaldehyde has been recognized as critically involved [32, 33], and this suggestion was further extended by the observation that another molecule, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), obtainable by Pictet-Spengler condensation of acetaldehyde and DA, could be responsible for the reinforcing properties of alcohol and for its addictive potential [34, 35]

Individuals with hypercholesterolemia exhibited approximately 42% lower plasma ALC levels than those of the general population (Figure 1A)

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