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These symptoms persist for a period ranging from 4 to 12 weeks in the case of ongoing symptomatic COVID-19 and extend beyond 12 weeks in the context of PCS, provided that a clear alternative diagnostic explanation is not present [7]

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In the present study, we tested whether -toxin disturbs G-CSF-mediated granulopoiesis and found that -toxin upregulates the production of G-CSF from endothelial cells by promoting pathogenic ligand-induced TLR signaling in vivo and in vitro, whereas -toxin makes neutrophils insensitive to G-CSF by reducing the expression of its receptor, which could be relevant to the -toxin-mediated blockage of granulopoiesis (Fig