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Within the context of purine nucleotide biosynthesis, fumarate is generated by the actions of adenylosuccinate lyase in the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to 5-aminoimidazole-4-carboxamide ribotide (AICAR) and in the conversion of adenylosuccinate to AMP
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While researchers had long been attempting to treat Alzheimer's by removing amyloid proteins from the brain, Ashe's team identified a specific target
