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Initial antioxidant and detoxification benefits may begin within 24 weeks, while visible skin improvements typically take 612 weeks of consistent use

A recent Cochrane review (8 studies, 640 participants) was not able to determine if ultra-long GnRH agonist cycles impacted livebirth (RR 0.48, 95% CI: 0.260.87) and clinical pregnancy rates (RR 0.48, 95% CI: 0.260.87) or mean number of oocytes (MD 0.72, 95% CI: 0.061.38) or embryos (MD -0.76, 95% CI: -1.33 to -0.19) as the quality of evidence was very low

This suggests that combining exercise interventions with phytomedicine may produce synergistic therapeutic effects