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ROS can lead to NLRP3 activation through binding to thioredoxin-interacting protein (TXNIP) binding following thioredoxin oxidation (Zhou et al., 2011)
1.14 - Free Radicals and Reactive Oxygen Species
Additionally, inflammatory signals and the overload in intracellular calcium ion could be also implicated in this complex network that has not yet been elucidated
Prione LP, Olchanheski LR, Tullio LD, Santo BC, Reche PM, Martins PF, Carvalho G, Demiate IM, Pileggi SA, Dourado MN (2016) GST activity and membrane lipid saturation prevents mesotrione-induced cellular damage in Pantoea ananatis
