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Moreover, disruption of the immune system associated with vigorous exercise has been reported to lead to problems during training and the poor physical condition of athletes, such as in overtraining syndrome (MacKinnon 2000;Smith 2003)

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674 In a TBI mouse model, HBED treatment can reduce microglia proliferation and aquaporin 4 expression, thereby alleviating secondary injury in the cortical region after TBI and improving motor function in mice

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