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A number of in vitro, in vivo , and ex vivo studies in humans have documented the ability of MEL to increase expression of multiple antioxidant stress genes, including copper zinc and manganese superoxide dismutases, glutathione peroxidase, catalase, and -glutamylcysteine synthase ( GSH1 , GPX1 , CTT1 , CTA1 , SOD1 , and SOD2 mRNA ( S
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