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In addition, the intracranial administration of Hu5F9-G4 can inhibit the dissemination of MB to leptomeninges while exerting minimal effects on healthy neural cells (158)

These findings underscore the growing burden of vitamin B 12 deficiency and highlight the need for routine screening, early detection, and prevention strategies to potentially mitigate its impact on healthcare systems

Detailed reviews on the protein markers of astrocytes present in different regions of the CNS as well as during inflammation and diseases have been published (268, 297, 298)