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While doses of radiation 12 kGy can effectively eliminate insects, the eradication of bacteria may necessitate higher radiation doses of up to 10 kGy (134)

Brizuela L, Richardson A, Marsischky G, Labaer J (2002) The FLEXGene repository: exploiting the fruits of the genome projects by creating a needed resource to face the challenges of the post- genomic era

In addition, a potentially reduced off-target toxicity compared to the cleavable linker conjugates is expectable, as non-cleavable ADCs can provide greater stability and tolerability

Furthermore, pyruvate dehydrogenase complex can translocate from the mitochondria to the nucleus (in a manner still unclear) during cell-cycle progression, generating a nuclear pool of acetyl-CoA from pyruvate and increasing the acetylation of core histones important for S phase entry as well as expression of damage-response genes among others (82