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Given that enzymes other than DHAR may also contribute to GSH oxidation under oxidative stress conditions (Figure 6), the relatively low capacity of GR may be important to allow GSSG accumulation to fulfil signaling functions

Oxidative stress in Alzheimers disease
R.YinP.Omar-HmeadiM.Ottosson LaaksoE.VikmanP.BargS

Alternatively the tablet(s) may be offered in food or hand-administered (pilled) as with other oral tablet medications
