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GSH depletion does not induce mitochondrial superoxide or alter mitochondrial mass in RPE cells It has been suggested that mitochondria are predominant source of ROS upon H 2 O 2 -induced oxidative stress 7
It also helps to reduce inflammation, and supports the body's natural ability to fight off infection
This increased LPO, which is a hallmark of ferroptosis, suggests a direct association between MG exposure and the induction of this specific type of cell death
