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Description
The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]
This may include growth hormone and IGF-1 production, skin cell proliferation, and muscle tissue growth
Because of these factors, oral supplements are best suited for mild deficiencies or preventive use
In very rare cases, they could have a severe allergic reaction called anaphylaxis
