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Synthesis of neurotransmitter GABA via the neuronal Tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

subsequently reported 11 cases of acquired 5-oxoprolinemia metabolic acidosis in patients ingesting acetaminophen (10)

The second intermediate host is consumed by a catfish and the metacercariae penetrate the intestine and migrate to the swim bladder and develop into an egg-producing adult [18]