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Understanding such metabolic transitions and how to modulate them is essential for the optimization of differentiation processes to ensure safe iPSC-derived cell therapies
10.4103/0973-1296.182154 65 HanM
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Both COX isoforms are heterodimers, with each subunit of the dimer containing an epidermal growth domain, membrane-binding domain, and catalytic domain where the cyclooxygenase and peroxidase active sites are found on either side of the heme prosthetic group (Rouzer and Marnett, 2009)
