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4.6.3 Motor neuron death and ferroptosis in ALS Selective motor neuron loss is a hallmark of ALS, and accumulating evidence supports a role for microglia-mediated inflammation as a non-cell-autonomous mechanism accelerating disease progression (365)
Caloric restriction, improvements in metabolic health, and reductions in adiposity independently influence DNA methylation patterns and epigenetic aging metrics, making it difficult to isolate the specific contribution of nutrient composition or individual bioactive compounds [46,47]

Ann Pharmacother 2009;43(2):304315

Plasma Metabolites as Possible Biomarkers for Diagnosis of Breast Cancer
