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Furthermore, in tumor cells where IGF-1R and INSR are co-expressed, upregulated INSR can compensate for IGF-1R inhibition, thereby limiting sustained inhibition of downstream signaling and contributing to resistance to IGF-1R-targeted therapy [25, 26]
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After injection, allow the vial to sit undisturbed at room temperature for 35 minutes
n = 5): Rats in this group were given a daily dosage of 25 mg/kg
