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A metabolome analysis disclosed that sulphasalazine triggers an increase in the glutamate-derived TCA cycle intermediate -ketoglutarate in addition to a decrease in cysteine and glutathione

Tsuji, N., Nishikori, S., Iwabe, O., Matsumoto, S., Shiraki, K., Miyasaka, H., Takagi, M., Miyamoto, K., & Hirata, K

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Moreover, the addition of bevacizumab to chemotherapy did not lead to an improvement in OS, which was 9.4 months versus 10.9 months in placebo and bevacizumab group respectively