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Current interventions for atherosclerosis that target these risk factors, such as first-line statins (which inhibit 3-hydroxy-3-methyl-glutaryl-CoA reductase and prevent it from decreasing the production of cholesterol) are beneficial in disease prevention and treatment

LPS Analysis LPS was analyzed by Limulus Amebocyte Lysate chromogenic assay (Lonza, Walkersville, MD) according to the manufacturer's instructions, with the following modifications: In the 104 CVID patients and 30 controls, samples were diluted 10-fold to avoid interference with background color, and preheated to 68C for 10 min prior to analyses to dissolve immune complexes as previously described (8, 17)

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