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26 These approaches show promise for creating stable, bioavailable oral peptide formulations that could revolutionize IBD treatment by maintaining efficacy while greatly improving patient compliance
In vivo studies show that such targeted enhancement can increase inhibitory neuron spiking, rebalance excitatory-inhibitory activity in the AC, and even prevent noise-induced tinnitus, offering a mechanism-based strategy that avoids general receptor blockade (Deng et al., 2020a)
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Hron-Milhavet L, Haluzik M, Yakar S, Gavrilova O, Pack S, Jou WC, Ibrahimi A, Kim H, Hunt D, Yau D, Asghar Z, Joseph J, Wheeler MB, Abumrad NA, LeRoith D
