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Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

doi: 10.1007/s40263-024-01113-z 52

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Medicines used in the treatment of hyperthyroidism have also been shown to have potential beneficial effects in relieving depressive symptoms