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The N-myristoylation of FSP1 is crucial for its specific localization to the plasma membrane, facilitating its role in ferroptosis suppression

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There is also increasing evidence that deregulation of GSH synthesis contributes to the pathogenesis of diseases such as diabetes mellitus, pulmonary and hepatic fibrosis, alcoholic liver disease, cholestatic liver injury, endotoxemia, and drug-resistant tumors cells [10]

At the end of the administration, we sacrificed the rats by intraperitoneal injection of 3% pentobarbital sodium (100 mg/kg), and the tissue samples were processed differently according to the different experimental protocols