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The elucidation of signaling pathways involved in the regulation of the tight junction would allow the identification of novel barrier-restoring agents, which is imperative for deciphering novel and potent approaches for disease treatment

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Conclusions The concept of the leaky gut, although used to explain the pathogenesis of many common diseases, should be rethought in terms of the available data that support the many means by which luminal substances cross the gut mucosal barrier