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Neuropathy causes nerve pain, including burning, tingling, and numbness
In the presymptomatic stages of appendicitis, biomarkers are not elevated, but elevations can occur within hours of symptom onset [7, 10]
doi: 10.1079/bjn19750005 87 HammondKA
the passage of bacteria or bacterial products such as endotoxin from the gut to the liver through portal bloodstream, these products will activate hepatic Kpffer cells, which can eliminate the enterogenous bacteria and toxins through phagocytosis, and induce severe systemic inflammation through releasing inflammatory mediators
